By NAMB
Copyright 2023 by NAMB all rights reserved
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I like to experiment with different writing styles. Here is one done
in the form of a scientific research paper although gratefully not at
long and missing the reams of data and charts that would normally
appear in such papers.
The
amphibian, Amazonium Maculosa Rana
(Amazon
Spotted Frog,) excretes a liquid from its skin that anesthetizes
predators that would otherwise eat it. Local tribes use this
secretion in combination with herbs from various plants in drinks to
produce a trance-like state for ceremonial purposes.
In
this paper, the authors discuss how the purified extract of these
potions is used in experimental drugs used to calm aggression in
humans.
There are a number of
drugs and treatment used to treat aggressive behavior. Most of them
have negative side effects including sleepiness, loss of continence,
addiction, loss of mental capacity and other effects that render the
patient less effective in society.
Amazonium
Maculosa Rana (AMR) extract has few, if any side effects
and
none of which are permanent once the use of the drug is terminated.
These affects are discussed in the following
sections.
Initial experimentation
started with ordinary laboratory mice: rattus norvegicus. In small
doses, it was noted that aggression in male mice was almost totally
lacking and that they often engaged in cooperative behaviors normally
associated with female mice such as grooming each other and tending
to offspring.
In larger doses, male mice exhibited
behavior associated with paranoia.
Female mice seem to be
unaffected by the drug.
In regulated doses, all mice were
otherwise normally active and there seemed to be no effect with other
health issues or life span.
It was also noted that
administering the drug to juvenile male mice, delayed the onset of
puberty and slowed sexual development. Introducing the drug later in
the mouse’s life reversed some of the secondary sexual
characteristics.
In managed doses these side effects can
be tolerated given the effectiveness of the primary purpose of the
drug.
Autopsies on the mice indicate normal brain
structure and tissue.
Upon successful completion of
testing with mice, we moved onto testing with chimpanzees. In
addition to being most closely related to us genetically, male
chimpanzees exhibit highly aggressive behaviors. There is constant
physical abuse in fights for dominance of the troop and chimpanzees
have been known to seek out and kill chimpanzees from other
troops.
The only other species this warlike is us. This
extreme aggression is precisely the behavior we wish to modify.
Male
chimpanzees, like the male mice became docile. The control group,
those not given the drug, fought among themselves and one of them
always became dominant male in the troop.
When isolated
from the control group, males on AMR did not fight among themselves
and seemed uninterested in being the dominant male. In fact, given
the non-aggression of the males, females in the troop took over and
the troop became a matriarchy much like their cousins the
bonobos.
Bonobo troops are female dominant. Male bonobos
groom females, fetch food for them and otherwise pamper them in
exchange for sexual favors.
Also, like the mice, chimp
“boys” on AMR entered puberty late and advanced
slowly. They
masturbated far less often than chimps in the control group. AMR did
not seem to lessen their sexual urges, but the AMR group seemed
hesitant to initiate sex leaving the control of sexual situations to
the females.
After observing the behavior for several
months, we started taking electroencephalograms to determine what
parts of the brain are affected by AMR.
Male AMR-treated
chimps were put into a number of situations such as being put back
into the control group, isolated by individual, isolated to just
other AMR chimps and finally in a mixed group with the
females.
The two areas of the brain
most affected by AMR are the amygdala (fear center) and substantia
nigra, ventral tegmental area, and hypothalamus – all of
which
produce pleasure-rewarding dopamine.
When placed back in
with the control group, the amygdala became more active than non-AMR
individuals introduced to the group.
Initially, the alpha
males attacked the AMR males but gave up quickly when the AMR males
failed to respond with aggression. The alpha males then concentrated
on competing with each other for dominance.
Brain activity
in the AMR males then returned to normal.
On their own, or
when with other AMR males, brain activity was also normal.
When
put with females, the brain activity changed.
Upon first
seeing a female, the amygdala has a minor spike in activity that
gradually declines. When doing any activity that is pleasing to a
female, dopamine is produced. Dopamine is produced in lesser amounts
when engaging in the same or similar activity with other males.
It
basically amounts to a male having a fear that a female will not
accept him and then realizing that pleasing her makes him feel
good.
Clinical tests on human subjects are scheduled for
Spring of 1962.
The drug was
eventually approved by the FDA and is marketed under the brand name,
Puericil. It is prescribed widely to curb male aggression, especially
in boys under the age of 18 and as young as 12. It has also been
found to abate the urges boys have for constant masturbation. Since
it is deemed that male masturbation is necessary for good health,
this task can be delegated to the girls in the boys’ lives.
Puericil makes acceptance of this practice by the boys common place.